四通胶囊治疗下肢深静脉血栓形成的疗效观察

来源:用户上传      作者:公茂旺 王颖超 陈孝华 王春红 王磊 尹梅

　　[摘要]目的探四通胶囊治疗下肢深静脉血栓（DVT）形成的临床疗效。方法选择2019年6月至2021年9 月在泰安市中医二院外科住院治疗的湿热下注证 DVT 患者60例为研究对象。按照随机数字表法分为观察组（ n=30）和对照组（ n=30）。观察组给予四通胶囊，对照组给予血塞通片，比较治疗后两组患者仍存在的临床症状情况、实验室指标及患侧肢体周径差变化，统计两组治疗安全性和临床效果。结果治疗后观察组仍存在患肢粗肿、患肢胀痛和患肢体征（粗肿、皮色、皮温、弹性）改变的比例均显著低于对照组（P <0.05）;治疗后观察组中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、D-二聚体和纤维蛋白原水平低于治疗后对照组（P <0.05）;观察组治疗前后患侧肢体周径减少比例大于对照组（ P <0.05）;观察组血常规异常、尿常规异常、大便常规异常、肝肾功能损伤、心电图异常及呼吸功能异常总发生率显著低于对照组（P <0.05）;观察组治愈率高于对照组（P <0.05），无效率低于对照组（ P <0.05）。结论四通胶囊治疗下肢 DVT 患者，可较快缓解患者临床症状，改善高凝状态，安全性和有效率均较理想。
　　[关键词]四通胶囊;下肢;深静脉血栓;临床症状;生化指标;并发症;有效性
　　[中图分类号] R259 [文献标识码] A [文章编号]2095-0616（2022）09-0107-04
　　Observation on the efficacy of Sitong Capsules in the treatment of lower extremity deep vein thrombosis
　　GONG Maowang WANG Yingchao CHEN Xiaohua WANG Chunhong WANG LeiYIN Mei
　　Department of Surgery， the Second Traditional Chinese Medicine Hospital ofTai'an， Shandong， Tai'an 271000， China
　　[Abstract] Objective To investigate the clinical efficacy of Sitong Capsules in the treatment of lower extremity deep vein thrombosis （DVT）. Methods A total of 60 DVT patients with syndrome of downward diffusion of damp-heat who were hospitalized in the Department of Surgery of the Second Traditional Chinese Medicine Hospital of Tai'an City from June 2019 to September 2021 were selected as the research objects. They were divided into the observation group （n=30） and the control group （n=30） according to the random number table method. The observation group received Sitong Capsules， while the control group received Xuesaitong Tablets. The clinical symptoms still existing after treatment were compared between the two groups， the changes in laboratory indexes and the difference in the circumference of the affected extremity were compared between the two groups before and after the intervention， and the safety and clinical efficacy of the treatment were calculated. Results After treatment， the proportions of swelling of the affected extremity， swelling and pain of the affected extremity and changes of the signs of the affected extremity （thickness， skin color， skin temperature， elasticity） in the observation group were significantly lower than those in the control group （P <0.05）. After treatment， the ratio of neutrophils to lymphocytes， the ratio of platelets to lymphocytes， and levels of D-dimer and fibrinogen in the observation group were lower than those in the control group （P <0.05）. The reduction proportion of the circumference of the affected extremity before and after treatment in the observation group was greater than that in the control group （P <0.05）. The total proportion of abnormal blood routine， abnormal urine routine， abnormal stool routine， liver and kidney function damage， abnormal electrocardiogram and abnormal respiratory function in the observation group were significantly lower than that in the control group （P <0.05）. The recovery rate of the observation group was higher than that of the control group （P <0.05）， and the ineffective rate was lower than that of the control group （P <0.05）. Conclusion Sitong Capsules in the treatment of lower extremity DVT patients can quickly relieve the clinical symptoms and improve the hypercoagulable state， with satisfactory safety and efficacy.

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