左旋维C联合Q开关Nd:YAG激光1?064?nm治疗更年期女性黄褐斑疗效观察

来源:用户上传      作者:鲁昆　陈敏　唐毅　李煌　周琰艳　丁建国

　　[摘要]目的：分析左旋SC联合Q开关Nd：YAG 1 064 nm激光治疗更年期女性黄褐斑患者的疗效。方法：选择2017年7月-2019年2月于笔者医院皮肤科诊治的86例女性更年期黄褐斑，随机分为对照组和观察组，每组43例。对照组采用Q开关Nd：YAG 1 064 nm激光治疗，每个月治疗1次;观察组在对照组的基础上采用超声导入联合口服左旋维C治疗，超声导入1次/周，口服3次/天，3粒/次，两组均持续治疗6个月。比较两组患者治疗总有效率、治疗前后黄褐斑面积及颜色、激素水平和治疗后不良反应发生率。结果：观察组总有效率（93.02%）显著高于对照组（74.42%），差异有统计学意义（P<0.05）。治疗后，两组血清FSH、E2、LPO、MSH水平、黄褐斑面积及颜色评分较治疗前降低，且观察组降低程度较对照组更明显（P<0.05）;血清SOD水平较治疗前升高，且观察组升高程度较对照组更高（P<0.05）;观察组不良反应发生率（6.98%）低于对照组（25.58%），差异有统计学意义（P<0.05）。结论：与单独使用Q开关Nd：YAG 1 064 nm激光治疗更年期女性黄褐斑相比，联合左旋维C能显著减小患者黄褐斑面积、淡化黄褐斑颜色、调节患者内分泌状态，其疗效更好，安全性更高，值得临床推广使用。
　　[关键词]Q开关Nd：YAG 1 064 nm激光;左旋维C;更年期;黄褐斑
　　[中图分类号]R758.4+2 [文献标志码]A [文章编号]1008-6455（2022）01-0061-04
　　Observation on the Curative Effect of L-Vitamin C Combined with Q-Switched Nd：YAG Laser 1 064 nm in the Treatment of Chloasma in Menopausal Women
　　LU Kun，CHEN Min，TANG Yi，LI Huang，ZHOU Yanyan，DING Jianguo
　　（Department of Dermatology，the First Affiliated Hospital，Traditional Chinese Medicine College of Hunan，Zhuzhou 412008，Hunan，China）
　　Abstract： Objective To analyze the therapeutic effect of L-vitamin C combined with Q-switched Nd：YAG 1 064 nm laser on menopausal women with chloasma. Methods A total of 86 menopausal women with melasma who were admitted to the department of dermatology at the author's hospital from July 2017 to February 2019 were randomly divided into a control group and an observation group， with 43 cases in each group. The control group was treated with Q-switched Nd：YAG 1 064 nm laser， 1 month/time，the observation group was treated with ultrasound combined with oral L-vitamin C on the basis of the control group， ultrasound was introduced 1 time/week， orally 3 times/day， 3 capsules/time， both groups continued treatment for 6 months. The total effective rate of treatment， the area and color of chloasma before and after treatment， hormone levels and the incidence of adverse reactions after treatment were compared between the two groups. Results The total effective rate of the observation group （93.02%） was significantly higher than that of the control group （74.42%）， and the difference was statistically significant （P<0.05）. After treatment， the levels of serum FSH， E2， LPO， MSH， chloasma area and color score of the two groups were lower than before treatment， and the degree of reduction in the observation group was more significant than that of the control group （P<0.05）. Serum SOD levels increased compared to before treatment High， and the degree of increase in the observation group was higher than that of the control group （P<0.05）. The incidence of adverse reactions in the observation group （6.98%） was lower than that of the control group （25.58%， P<0.05）. Conclusion Compared with Q-switch Nd：YAG 1 064 nm laser alone， combined with L-vitamin C for the treatment of menopausal chloasma can significantly reduce the area of chloasma， fade the color of chloasma， and regulate the endocrine status of patients. It has better efficacy and higher safety， and is worthy of clinical promotion.
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