硒酵母、左甲状腺素钠片联合治疗慢性淋巴细胞性甲状腺炎临床疗效观察

来源:用户上传      作者:张员霞

　　[摘要] 目的 探究硒酵母、左甲状腺素钠片联合治疗慢性淋巴细胞性甲状腺炎的临床疗效。方法 选取2019年1月至2020年6月江西省景德镇市第三人民医院收治的90例甲状腺功能减退慢性淋巴细胞性甲状腺炎患者，随机分为两组（单一组、联合组）。单一组（n=45）应用左甲状腺素钠片治疗，联合组（n=45）应用甲状腺素钠片和硒酵母治疗。记录勺橹瘟6个月后的临床疗效、血清甲状腺自身抗体水平和甲状腺功能变化情况。结果 治疗后，联合组的总有效率95.56%，高于对照组的总有效率73.33%，两组比较，差异有统计学意义（P<0.05）。治疗后，两组的甲状腺球蛋白抗体（TG-Ab）、抗甲状腺过氧化物酶抗体（TPO-Ab）、促甲状腺激素（TSH）水平均低于治疗前，血清游离三碘甲状腺原氨酸（FT3）、血清游离甲状腺素（FT4）水平均高于治疗前，联合组的TG-Ab、TPO-Ab、TSH水平均低于单一组，且FT3、FT4水平均高于单一组，差异有统计学意义（P<0.05）。结论 慢性淋巴细胞性甲状腺炎患者联合应用硒酵母、左甲状腺素钠片治疗，疗效显著，且可改善其甲状腺自身抗体水平及甲状腺功能。
　　[关键词] 硒酵母;左甲状腺素钠片;慢性淋巴细胞性甲状腺炎;甲状腺功能
　　[中图分类号] R581.4 [文献标识码] B [文章编号] 1673-9701（2022）13-0025-03
　　[Abstract] Objective To explore the clinical effect of selenium yeast and levothyroxine sodium tablets in the treatment of chronic lymphocytic thyroiditis. Methods A total of 90 patients with hypothyroidism and chronic lymphocytic thyroiditis who were admitted to Jingdezhen Third People′s Hospital from January 2019 to June 2020 were selected as the research subjects， and randomly divided into two groups （the single group and the combined group）. The single group （n=45） was treated with levothyroxine sodium tablets， while the combined group （n=45） was treated with thyroxine sodium tablets and selenium yeast. The clinical effect and the changes in serum thyroid autoantibody levels and thyroid function after 6 months of treatment were recorded in both groups. Results After treatment， the total effective rate of the combined group was 95.56%， which was higher than 73.33% of the control group， and the difference between the two groups was statistically significant （P<0.05）. After treatment， the levels of thyroglobulin antibody （TG-Ab）， anti-thyroid peroxidase antibody （TPO-Ab） and thyroid stimulating hormone （TSH） were lower than those before treatment， and the levels of serum free triiodothyronine （FT3） and serum free thyroxine （FT4） were higher than those before treatment， with statistically significant differences （P<0.05）. The levels of TG-Ab， TPO-Ab and TSH in the combined group were lower than those in the single group， and the levels of FT3 and FT4 were higher than those in the single group， and the differences between the two groups were statistically significant （P<0.05）. Conclusion In patients with chronic lymphocytic thyroiditis， the combined application of selenium yeast and levothyroxine sodium tablet has a significant curative effect， and can improve the levels of thyroid autoantibody and thyroid function.

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