果酸换肤、表皮生长因子凝胶联合优创硅酮敷料治疗痤疮瘢痕疗效观察

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　　[摘要]目的：探析果酸Q肤、表皮生长因子凝胶联合优创硅酮敷料在痤疮瘢痕中治疗效果观察。方法：选取2019年8月-2020年12月在笔者医院接诊的痤疮瘢痕患者148例，数字表法分为优创组49例、双药组49例、多药组50例，优创组给予优创硅酮敷料单药治疗，双药组给予果酸换肤+表皮生长因子凝胶治疗，多药组给予果酸换肤+表皮生长因子凝胶+优创硅酮敷料联合治疗。对比各组患者痤疮瘢痕权重评分（ECCA）、生活质量评分，检测炎症因子水平（IL-10、IL-17、TNF-α）、皮肤屏障功能，记录三组痤疮瘢痕改善时间，结痂持续时间，痂皮脱落时间，并对比临床疗效。结果：治疗后，与优创组、双药组相比，多药组红斑持续时间、结痂持续时间及痂皮脱落时间较短，ECCA权重评分较低（P<0.05）。治疗后，患者血清IL-10、IL-17、TNF-α水平、角质层蛋白质、乳酸刺激实验、TEWL水平均有所降低，角质层含水量、Acne-QOL量表评分升高（P<0.05）;且多药组血清IL-10、IL-17、TNF-α水平、角质层蛋白质、乳酸刺激实验、TEWL水平低于优创组、双药组，角质层含水量、Acne-QOL量表评分高于优创组、双药组（P<0.05）。多药组临床有效率明显高于优创组、双药组（P<0.05）。结论：在优创硅酮凝胶敷料基础上联合果酸换肤、人表皮生长因子凝胶治疗痤疮瘢痕患者疗效显著。缩短创面结痂及痂皮脱落时间，减轻炎症反应及瘢痕损伤，促进皮肤屏障功能修复，生活质量提升，疗效显著。
　　[关键词]果酸换肤;重组人表皮生长因子凝胶;优创硅酮敷料;痤疮瘢痕
　　[中图分类号]R619+.6 [文献标志码]A [文章编号]1008-6455（2022）05-0014-05
　　Acnes Scars Treated with Fruity Skin Dressing，Epidermal Growth Factor Gel Combined with Eugenistein Dressings
　　XIE Ronggui1，ZHU Xianggong2
　　[1.Department of Dermatology，the Second People's Hospital of Lianyungang（Lianyungang Cancer Hospital），Lianyungang 222000，Jiangsu，China; 2.Department of Dermatology，People's Hospital of Hongze District，Huai'an 223100，Jiangsu，China]
　　Abstract： Objective To explore the therapeutic effect of fruity skin dressing， epidermal growth factor gel combined with eugenistein dressing in acne scars. Methods 148 acne scar patients who visited our hospital from August 2019 to December 2020 were selected， and the digital table method was divided into eugenics group （49 cases）， dual drug group （49 cases）， multi drug group （50 cases）， two eugenics group was given single drug treatment of eugenics silicone dressing， dual drug group was given acid peels， epidermal growth factor gel （EGF） treatment， another multi drug group was given acid peelsCombination therapy with epidermal growth factor gel， eugenidione dressings. Acne scar weight score （ECCA）， and quality of life scores were compared between the two groups， and inflammatory factors Level （IL-10， IL-17， TNF-α）， record the time of acne scar improvement， duration of scab， and time of scab shedding in three groups， skin barrier function， and compare clinical efficacy. Results After treatment， erythema duration， scabbing duration and scab shedding time were shorter and ECCA weight score was lower （P<0.05） in the multi drug group compared to the Yichuang and dual drug groups.After treatment， serum IL-10， IL-17， TNF-α Levels， stratum corneum proteins， lactic acid stimulation experiments， TEWL levels were reduced and stratum corneum water content， acne QOL scale score increased （P<0.05）.Moreover， serum IL-10， IL-17， TNF-α Levels， stratum corneum proteins， lactic acid stimulation experiments， TEWL levels were lower than those in the atraumatic and dual drug groups， and stratum corneum water content and acne QOL scale scores were higher than those in the atraumatic and dual drug groups （P<0.05）.The clinical response rate in the polypharmacy group was significantly higher than that in the optimizer， dual drug group （P<0.05）. Conclusion Acnes scar patients treated with a combination of acid changing， human epidermal growth factor gel based on eugenidione gel dressing.It can shorten the time of wound scabbing and scab shedding， attenuate the inflammatory response and scar damage， promote the skin barrier function repair， improve the quality of life， and have significant efficacy.

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