血压变异性对老年高血压患者冠脉病变程度的预测价值
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【摘要】 目的:探讨并分析血压变异性对老年高血压患者冠脉病变程度的预测价值。方法:将210例来笔者所在医院进行诊治的老年高血压患者给予冠状动脉造影,根据造影结果分为观察组(115例)和对照组(95例),并将观察组根据Gensini评分分为轻度组(49例)、中度组(37例)和重度组(29例)。分别比较各组血压变异性,并通过Pearson相关性分析血压变异性与冠脉病变程度相关指标的关系。结果:观察组患者24 h SCV、24 h DCV、dSCV、dDCV、nSCV、nDCV均明显高于对照组(P<0.05);中、重度组相关指标均显著高于轻度组,且重度组显著高于中度组(P<0.05)。Pearson相关分析显示,24 h SCV、24 h DCV、dSCV、dDCV、nSCV、nDCV均与Gensini评分呈正相关(P<0.05)。
结论:在老年高血压患者中,血压变异性较大的患者更容易发生冠脉病变,降低血压变异性可能对减少血管损伤有意义。
【关键词】 老年高血压; 血压变异性; 冠脉病变程度; 预测价值
doi:10.14033/j.cnki.cfmr.2019.10.036 文献标识码 B 文章编号 1674-6805(2019)10-00-03
Predictive Value of Blood Pressure Variability on Coronary Artery Lesion in Elderly Patients with Hypertension/DENG Yi.//Chinese and Foreign Medical Research,2019,17(10):-77
【Abstract】 Objective:To investigate and analyze the predictive value of blood pressure variability on coronary artery disease in elderly patients with hypertension.Method:A total of 210 elderly patients with hypertension were selected and divided into observation group(n=115) and control group(n=95) according to the results of coronary angiography.The observation group was divided into mild group(n=49),moderate group(n=37) and severe group(n=29) according to Gensini score.The blood pressure variability were compared among the groups,and the correlation between blood pressure variability and coronary artery lesion degree were analyzed by Pearson correlation analysis.The relationship between indicators.Result:24 h SCV,24 h DCV,dSCV,dDCV,nSCV,nDCV in the observation group were significantly higher than those in the control group(P<0.05),and the relative indexes in the moderate and severe group were significantly higher than those in the mild group and the moderate group(P<0.05),and in the severe group were significantly higher than those in the moderate group(P<0.05).Pearson correlation analysis showed that 24 h SCV,24 h DCV,dSCV,dDCV,nSCV and nDCV were positively correlated with Gensini score(P<0.05).
Conclusion:In elderly patients with hypertension,patients with higher blood pressure variability are more likely to develop coronary artery disease,lowering blood pressure variability may be of significance in reducing vascular injury.
【Key words】 Elderly hypertension; Blood pressure variability; Severity of coronary artery disease; Predictive value
First-author’s address:Xiaogan Central Hospital,Xiaogan 432000,China
老年高血壓是由环境因素、膳食、精神紧张、吸烟及饮酒等各种因素的影响下,致使血压的调节功能失调而产生,被认为是冠心病等心脑血管疾病发生危险因素[1]。近年来,随着生活水平的不断提高及老龄人口化的增加,24 h动态血压监测在临床上的普遍应用,血压变异性(BPV)已受到越来越多的关注。有研究结果表明,血压变异性与心脑血管时间有关,被认为是冠心病发生独立危险因子之一[2-3]。临床实践证实,血压变异性的升高与心血管疾病严重程度患者长期预后相关,并认为血压变异性可加重心肌缺血程度[4]。目前相关文献偏向分析血压变异性与冠脉病变程度之间的关系,其Gensini评分是公认的冠脉病变程度的定量评价方式[5]。基于此,本研究通过对老年高血压患者血压变异性与冠脉病变程度的关系进行分析,为临床防治提供参考。 综上所述,老年高血压患者多表现为血压变异性大,且与冠脉病变程度存在明显的相关性,血压变异性也可能是冠脈病变发生发展的独立预测指标。
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