分析临床上采用丹参川芎嗪注射液辅助治疗急性脑梗死的疗效

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　　[摘要] 目的 探讨分析临床上采用丹参川芎嗪注射液辅助治疗急性脑梗死的疗效。方法 方便选择该院2017年10月—2018年10月收治的100例急性脑梗死患者作为研究对象，按照随机数字表法分成两组。两组均接受常规治疗，在此基础上，对照组联合血塞通辅助治疗，研究组则联合丹参川芎嗪注射液辅助治疗。比较分析两组治疗效果、治疗前后主要证候评分、治疗前后血液流变学指标水平以及不良反应。 结果 研究组的治疗总有效率为96.0%，高于对照组，差异有统计学意义（χ2=5.0，P<0.05）;研究组治疗前的半身不遂评分[（4.20±1.02）分]、口舌斜评分[（4.05±0.92）分]、言语蹇涩评分[（4.16±0.95）分]、乏力短气评分[（3.98±0.82）分]、舌淡苔薄评分（3.75±0.90）分、脉细弱评分[（4.00±0.85）分]，與对照组差异无统计学意义（t=0.1，0.2，0.2，0.1，0.1，0.1，P>0.05）;研究组治疗后的半身不遂评分[（0.85±0.20）分]、口舌斜评分[（0.71±0.21）分]、言语蹇涩评分[（0.72±0.16）分]、乏力短气评分[（0.72±0.15）分]、舌淡苔薄评分[（0.72±0.19）分]、脉细弱评分[（0.70±0.15）分]，均低于对照组，差异有统计学意义（t=5.8，8.2，8.2，8.3，7.2，8.7，P<0.05）;研究组治疗前的全血高切黏度[（6.75±0.71）mPa·s]、全血低切黏度[（50.10±9.21）mPa·s]、血细胞比容[（46.65±7.65）%]、纤维蛋白原[（8.70±1.62）g/L]、血小板聚集率[（3.90±0.75）%]，均与对照组差异无统计学意义（P>0.05）;研究组治疗后的全血高切黏度[（5.38±0.46）mPa.s]、全血低切黏度[（37.30±5.70）mPa·s]、血细胞比容[（14.65±2.98）%]、纤维蛋白原[（4.20±0.90）g/L]、血小板聚集率[（1.93±0.30）%]，均低于对照组，差异有统计学意义（t=5.7，3.4，15.6，6.9，10.2，P<0.05）;研究组的不良反应发生率为8.0%，与对照组差异无统计学意义（χ2=0.2，P>0.05）。 结论 急性脑梗死采用丹参川芎嗪注射液辅助治疗的疗效确切。
　　[关键词] 丹参川芎嗪注射液;辅助治疗;急性脑梗死;疗效
　　[中图分类号] R743.3          [文献标识码] A          [文章编号] 1674-0742（2019）08（a）-0088-03
　　[Abstract] Objective To analyze the clinical efficacy of Danshen Ligustrazine Injection in the treatment of acute cerebral infarction. Methods Convenient 100 patients with acute cerebral infarction who were admitted from October 2017 to October 2018 were enrolled in the study. They were divided into two groups according to the random number table method. Both groups received routine treatment. On this basis， the control group was treated with Xuesaitong adjuvant therapy， and the study group was treated with Danshen ligustrazine injection. The therapeutic effects of the two groups， the main syndrome score before and after treatment， the blood rheology index before and after treatment， and the adverse reactions were compared. Results The total effective rate of the study group was 96.0%， which was higher than that of the control group，the difference was statistically significant（χ2=5.0， P<0.05）. The hemiplegia score of the study group before treatment [（4.20±1.02） points] and the tongue and tongue skew score [（4.05±0.92） points]， speech bitterness score [（4.16±0.95） points]， fatigue short gas score [（3.98±0.82） points]， tongue pale moss thin score （3.75±0.90）points， pulse weak score [（4.00±0.85） points]， no difference with the control group （t=0.1， 0.2， 0.2， 0.1， 0.1， 0.1， P>0.05）; the hemiplegia score of the study group after treatment [（0.85±0.20） points]， tongue slant score [（0.71±0.21） points]， speech bitterness score [（0.72±0.16） points]， fatigue short gas score [（0.72±0.15） points]， tongue pale moss score [（0.72±0.19） points]， The weak pulse score，the difference was statistically significant[（0.70±0.15） points] was lower than the control group （t=5.8， 8.2， 8.2， 8.3， 7.2， 8.7， P<0.05）; the whole blood high-viscosity of the study group before treatment [（6.75±0.71）mPa·s]， whole blood low-cut viscosity [（50.10±9.21）mPa·s]， hematocrit [（46.65±7.65）%]， fibrinogen [（8.70±1.62） g/L]， platelet aggregation rate [（3.90±0.75）%]， the difference wasnot statistically significant with the control group （P>0.05）; whole blood high-viscosity [（5.38±0.46）mPa·s]， whole blood low-cut viscosity [（37.30±5.70） mPa·s]， hematocrit [14.65±2.98）%]， fibrinogen [（4.20±0.90）g/L]， platelet aggregation rate [（1.93±0.30）%]， all lower than the control group，the difference was statistically significant（t=5.7， 3.4， 15.6， 6.9， 10.2， P<0.05）; the incidence of adverse reactions in the study group was 8.0%， no difference from the control group（χ2=0.2， P>0.05）. Conclusion The treatment of acute cerebral infarction with Danshen Ligustrazine Injection is effective.
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